RNF141

Across TCGA patient cohorts, RNF141 mutation is significantly associated with the RNA expression of many other genes, with 2,316 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF141-associated genes across cancer lineages are HMGN1P20, RNU6-871P, and IGHD6-19. Each is linked with RNF141 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF141-to-partner and partner-to-RNF141 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGN1P20 grouped by RNF141-low versus RNF141-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF141→partner) and Y-score (partner→RNF141) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	HMGN1P20 →	+0.245	+4.971	<.001	.002	3	2
BLCA	RNU6-871P →	+0.309	+4.788	<.001	.006	3	2
UCEC	IGHD6-19 →	+0.323	+2.042	.002	.008	3	2
UCEC	RNA5SP413 →	+0.628	+1.614	.001	.002	3	2
BLCA	BTF3P1 →	+0.149	+4.208	<.001	.009	3	2
UCEC	LINC01943 →	+0.350	+1.555	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,316 associations by consensus.

HMGN1P20 by RNF141 expression — BLCA

Explore this box plot interactively →