RNF141

Across TCGA patient cohorts, RNF141 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF141-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and eIF4E. Each is linked with RNF141 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF141-to-partner and partner-to-RNF141 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RNF141-low versus RNF141-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF141→partner) and Y-score (partner→RNF141) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.110	-2.673	.002	.005	3	1
UCEC	EGFR_pY1068 →	-0.197	-1.584	.029	.019	3	1
UCEC	eIF4E →	+0.200	+1.925	.008	.005	3	1
UCEC	A-Raf_pS299 →	-0.118	-1.807	.006	.025	3	1
UCEC	FOXO3a_pS318_S321 →	-0.108	-2.312	.016	.005	3	1
UCEC	GSK3-a-b →	+0.110	+3.321	.024	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

14-3-3_beta by RNF141 expression — UCEC

Explore this box plot interactively →