RNF14

Across TCGA pan-cancer cohorts, RNF14 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated RNF14 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RNF14 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF14 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

LSCC, GBM, and COAD are the cancer types where RNF14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.433	0.897	<.001	17	view →
GBM	DFS	Tertile	All	0.291	0.475	.008	10	view →
COAD	DFS	Median	III,IV	0.835	1.000	.040	6	view →
CCRCC	OS	Median	All	0.749	0.921	.013	6	view →
PDAC	OS	Quartile	All	0.897	0.745	.021	5	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	4	view →
UCEC	DFS	Tertile	III,IV	1.000	0.539	.049	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

RNF14–LSCC (DFS)

Open the LSCC breakdown →