RNF14

Across TCGA patient cohorts, RNF14 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF14-associated genes across cancer lineages are Cyclin-B1, eEF2, and ERK2. Each is linked with RNF14 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF14-to-partner and partner-to-RNF14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by RNF14-low versus RNF14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF14→partner) and Y-score (partner→RNF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.570	+2.000	.024	.032	3	2
UCEC	eEF2 →	+0.401	+2.000	.012	.032	3	1
UCEC	ERK2 →	+0.234	+2.000	.007	.032	3	1
UCEC	GAPDH →	+0.487	+2.000	.044	.032	3	1
UCEC	GATA6 →	-0.150	-1.992	.031	.031	3	1
UCEC	IGFBP2 →	-0.747	-2.321	.010	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Cyclin-B1 by RNF14 expression — UCEC

Explore this box plot interactively →