RNF139

Across TCGA pan-cancer cohorts, RNF139 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RNF139 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher RNF139 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RNF139 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

PDAC, LUAD, and GBM are the cancer types where RNF139 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.351	0.813	.001	38	view →
LUAD	OS	Median	III,IV	0.743	0.223	.001	13	view →
GBM	DFS	Quartile	All	0.817	0.652	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

RNF139–PDAC (OS)

Open the PDAC breakdown →