RNF138

Across TCGA pan-cancer cohorts, RNF138 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RNF138 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RNF138 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RNF138 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, UCEC, and LUAD are the cancer types where RNF138 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.790	0.178	.006	27	view →
UCEC	OS	Median	II,III,IV	1.000	0.605	.023	12	view →
LUAD	OS	Quartile	All	0.634	0.878	.023	8	view →
PDAC	DFS	Tertile	All	0.668	0.847	.029	3	view →
LSCC	DFS	Median	II,III,IV	0.498	0.919	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RNF138–CCRCC (DFS)

Open the CCRCC breakdown →