RNF135

Across TCGA pan-cancer cohorts, RNF135 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RNF135 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RNF135 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RNF135 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where RNF135 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.633	0.233	.010	22	view →
PDAC	OS	Tertile	III,IV	0.908	0.601	.004	11	view →
LSCC	DFS	Quartile	II,III,IV	0.517	0.828	.012	9	view →
GBM	OS	Quartile	All	0.881	1.000	.022	4	view →
LUAD	OS	Quartile	All	0.485	0.908	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RNF135–CCRCC (DFS)

Open the CCRCC breakdown →