RNF130

Across TCGA patient cohorts, RNF130 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF130-associated genes across cancer lineages are eIF4E, EGFR_pY1068, and ACC1. Each is linked with RNF130 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF130-to-partner and partner-to-RNF130 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RNF130-low versus RNF130-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF130→partner) and Y-score (partner→RNF130) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.177	+2.000	.032	.010	3	2
UCEC	EGFR_pY1068 →	-0.210	-1.584	.033	.036	3	1
UCEC	ACC1 →	+0.281	+3.013	.049	.018	3	1
UCEC	MEK1 →	+0.365	+2.700	.010	.006	3	1
UCEC	Notch1 →	+0.137	+1.887	.013	.029	3	1
UCEC	p90 RSK →	+0.167	+1.594	.026	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

eIF4E by RNF130 expression — UCEC

Explore this box plot interactively →