RNF130

Across TCGA cell cohorts, RNF130 mutation is significantly associated with the drug of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF130-associated genes across cancer lineages are Niraparib, Luminespib, and VSP34_8731. Each is linked with RNF130 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF130-to-partner and partner-to-RNF130 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by RNF130-low versus RNF130-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF130→partner) and Y-score (partner→RNF130) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.387	+2.646	.029	.047	3	1
LARGE_INTESTINE	Luminespib →	+0.651	+2.646	.032	.047	3	1
LARGE_INTESTINE	VSP34_8731 →	+0.410	+2.649	.042	.046	3	1
LARGE_INTESTINE	50869 →	+0.448	+2.649	.034	.046	3	1
LARGE_INTESTINE	150412 →	+0.376	+2.777	.025	.038	3	1
LARGE_INTESTINE	CDK9_5576 →	+0.642	+2.649	.013	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Niraparib by RNF130 expression — LARGE_INTESTINE

Explore this box plot interactively →