RNF13

Across TCGA cell cohorts, RNF13 mutation is significantly associated with the drug of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF13-associated genes across cancer lineages are Alisertib, OSI-027, and Taselisib. Each is linked with RNF13 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF13-to-partner and partner-to-RNF13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Alisertib grouped by RNF13-low versus RNF13-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF13→partner) and Y-score (partner→RNF13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Alisertib →	+0.791	+2.646	.029	.047	3	1
LARGE_INTESTINE	OSI-027 →	+0.561	+2.769	.009	.040	3	1
LARGE_INTESTINE	Taselisib →	+0.542	+2.646	.027	.047	2	1
LARGE_INTESTINE	MK-2206 →	+0.560	+2.646	.036	.047	1	1
LARGE_INTESTINE	Uprosertib →	+0.744	+2.646	.013	.047	1	1
LARGE_INTESTINE	LY2109761 →	+0.390	+2.646	.019	.047	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Alisertib by RNF13 expression — LARGE_INTESTINE

Explore this box plot interactively →