RNF123

Across TCGA pan-cancer cohorts, RNF123 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RNF123 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher RNF123 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF123 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where RNF123 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	II,III,IV	0.651	0.985	<.001	22	view →
CCRCC	DFS	Median	All	0.900	0.719	.004	18	view →
LUAD	DFS	Median	II,III,IV	0.714	0.944	.033	5	view →
HNSC	DFS	Tertile	III,IV	0.828	0.579	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RNF123–PDAC (DFS)

Open the PDAC breakdown →