RNF123

Across TCGA patient cohorts, RNF123 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF123-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and JNK_pT183_Y185. Each is linked with RNF123 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF123-to-partner and partner-to-RNF123 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RNF123-low versus RNF123-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF123→partner) and Y-score (partner→RNF123) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.227	-1.643	.003	.003	3	2
UCEC	eIF4E →	+0.173	+2.598	.008	.005	3	2
COAD	JNK_pT183_Y185 →	-0.211	-3.321	.039	.009	3	2
UCEC	PCNA →	+0.191	+1.514	.004	.014	3	2
UCEC	PDCD4 →	-0.499	-1.643	<.001	.003	3	2
UCEC	Rad50 →	-0.151	-1.201	.044	.028	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

EGFR_pY1068 by RNF123 expression — UCEC

Explore this box plot interactively →