RNF123

Across TCGA cell cohorts, RNF123 mutation is significantly associated with the RNA expression of many other genes, with 2,021 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF123-associated genes across cancer lineages are NEUROG1, FCN3, and DPPA2. Each is linked with RNF123 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF123-to-partner and partner-to-RNF123 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEUROG1 grouped by RNF123-low versus RNF123-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF123→partner) and Y-score (partner→RNF123) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NEUROG1 →	+0.003	+4.058	<.001	.009	3	2
BLOOD_Lymphoma	FCN3 →	+0.032	+3.954	.001	.005	3	1
BLOOD_Lymphoma	DPPA2 →	+0.188	+3.523	<.001	.009	3	1
BLOOD_Lymphoma	GYPA →	+0.075	+3.847	<.001	.006	3	1
BLOOD_Lymphoma	PYDC2 →	+0.088	+4.662	<.001	.003	3	1
SKIN	SLC7A14 →	+0.545	+3.772	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,021 associations by consensus.

NEUROG1 by RNF123 expression — BLOOD_Lymphoma

Explore this box plot interactively →