RNF121

Across TCGA pan-cancer cohorts, RNF121 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RNF121 data layer compared with 21 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RNF121 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RNF121 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where RNF121 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.716	0.898	.005	11	view →
LUAD	DFS	Median	III,IV	0.409	1.000	.024	6	view →
CCRCC	DFS	Tertile	All	1.000	0.483	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

RNF121–LSCC (OS)

Open the LSCC breakdown →