RNF121

Across TCGA patient cohorts, RNF121 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF121-associated genes across cancer lineages are 4E-BP1_pT37_T46, cIAP, and Cyclin-E2. Each is linked with RNF121 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF121-to-partner and partner-to-RNF121 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT37_T46 grouped by RNF121-low versus RNF121-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF121→partner) and Y-score (partner→RNF121) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT37_T46 →	-0.542	-3.169	.008	.020	3	1
UCEC	cIAP →	+0.158	+2.817	.036	.036	3	1
UCEC	Cyclin-E2 →	+0.241	+3.169	.009	.020	3	1
UCEC	A-Raf_pS299 →	-0.158	-3.000	.015	.036	2	1
UCEC	Ku80 →	+0.366	+3.183	.004	.010	2	1
UCEC	Akt_pS473 →	-0.824	-3.169	.035	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

4E-BP1_pT37_T46 by RNF121 expression — UCEC

Explore this box plot interactively →