RNF121

Across TCGA cell cohorts, RNF121 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNF121-associated genes across cancer lineages are OR56A5, IQCF5, and SLC6A5. Each is linked with RNF121 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF121-to-partner and partner-to-RNF121 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A5 grouped by RNF121-low versus RNF121-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF121→partner) and Y-score (partner→RNF121) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.056	+5.357	<.001	.003	3	1
BLOOD_Leukemia	SLC6A5 →	+0.014	+4.551	.005	.004	3	1
BLOOD_Leukemia	LCE2A →	+0.053	+4.969	<.001	.003	3	1
BLOOD_Leukemia	CBLN4 →	+0.004	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR56A5 by RNF121 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →