RNF114

Across TCGA pan-cancer cohorts, RNF114 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RNF114 data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RNF114 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF114 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where RNF114 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.547	0.959	<.001	65	view →
LUAD	DFS	Quartile	III,IV	0.877	0.366	.019	5	view →
LSCC	DFS	Quartile	All	0.797	0.224	.002	2	view →
GBM	OS	Quartile	All	0.605	0.815	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RNF114–CCRCC (DFS)

Open the CCRCC breakdown →