RNF114

Across TCGA cell cohorts, RNF114 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,633 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RNF114-associated GO terms across cancer lineages are IRE1-mediated unfolded protein response, Regulation by virus of viral protein levels in host cell, and Protein linear deubiquitination. Each is linked with RNF114 in more than 14 cancer types. Because this analysis shows association rather than direction, both RNF114-to-partner and partner-to-RNF114 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRE1-mediated unfolded protein response grouped by RNF114-low versus RNF114-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF114→partner) and Y-score (partner→RNF114) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IRE1-mediated unfolded protein response →	+0.164	+1.056	<.001	<.001	3	15
KIDNEY	Regulation by virus of viral protein levels in host cell →	+0.161	+0.747	<.001	.002	3	13
SOFT_TISSUE	Protein linear deubiquitination →	+0.375	+0.573	.002	<.001	3	13
BLOOD_Leukemia	Positive regulation by virus of viral protein levels in host cell →	+0.118	+0.709	<.001	<.001	3	12
PANCREAS	Regulation of tumor necrosis factor-mediated signaling pathway →	+0.080	+0.592	.001	.004	3	11
KIDNEY	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.184	+0.972	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,633 associations by consensus.

IRE1-mediated unfolded protein response by RNF114 expression — OVARY

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