RNF113A

Across TCGA patient cohorts, RNF113A mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF113A-associated genes across cancer lineages are Cyclin-B1, EGFR_pY1068, and eIF4E. Each is linked with RNF113A in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF113A-to-partner and partner-to-RNF113A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by RNF113A-low versus RNF113A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF113A→partner) and Y-score (partner→RNF113A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.551	+1.736	.004	.007	3	2
UCEC	EGFR_pY1068 →	-0.202	-2.000	.020	.029	3	1
UCEC	eIF4E →	+0.146	+2.321	.046	.005	3	1
UCEC	A-Raf_pS299 →	-0.104	-2.000	.011	.030	3	1
UCEC	FOXO3a_pS318_S321 →	-0.087	-1.668	.043	.021	3	1
UCEC	GATA6 →	-0.150	-2.444	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Cyclin-B1 by RNF113A expression — UCEC

Explore this box plot interactively →