RNF111

Across TCGA patient cohorts, RNF111 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF111-associated genes across cancer lineages are PCNA, Rictor_pT1135, and Caveolin-1. Each is linked with RNF111 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF111-to-partner and partner-to-RNF111 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by RNF111-low versus RNF111-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF111→partner) and Y-score (partner→RNF111) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.264	+3.999	<.001	<.001	3	3
UCEC	Rictor_pT1135 →	-0.066	-1.678	.034	.021	3	3
BLCA	Caveolin-1 →	-0.666	-2.999	.041	.035	3	2
UCEC	ERK2 →	+0.180	+1.700	.002	.001	3	2
UCEC	INPP4B →	-0.231	-2.247	.019	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.158	-2.502	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

PCNA by RNF111 expression — UCEC

Explore this box plot interactively →