RNF111

Across TCGA cell cohorts, RNF111 mutation is significantly associated with the RNA expression of many other genes, with 77 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF111-associated genes across cancer lineages are AGXT2, XAGE5, and LIPG. Each is linked with RNF111 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF111-to-partner and partner-to-RNF111 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGXT2 grouped by RNF111-low versus RNF111-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF111→partner) and Y-score (partner→RNF111) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	AGXT2 →	+0.103	+4.906	<.001	.006	3	1
OVARY	XAGE5 →	+0.255	+5.196	<.001	.005	3	1
LARGE_INTESTINE	LIPG →	+1.609	+3.169	.001	.009	3	1
LARGE_INTESTINE	MANBA →	+0.697	+3.364	.005	.002	3	1
LARGE_INTESTINE	OSBP →	+0.746	+3.364	<.001	.002	3	1
LARGE_INTESTINE	PDE10A →	+1.019	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

AGXT2 by RNF111 expression — OESOPHAGUS

Explore this box plot interactively →