RNF11

Across TCGA pan-cancer cohorts, RNF11 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated RNF11 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RNF11 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RNF11 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where RNF11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.963	0.586	.001	30	view →
LUAD	DFS	Tertile	II,III,IV	0.633	0.980	.003	24	view →
CCRCC	OS	Median	All	0.987	0.662	.026	10	view →
UCEC	DFS	Median	All	1.000	0.847	.029	6	view →
LSCC	DFS	Median	All	0.624	0.830	.030	5	view →
GBM	DFS	Quartile	All	0.415	0.223	.033	2	view →
PDAC	OS	Quartile	II,III,IV	0.788	1.000	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

RNF11–HNSC (OS)

Open the HNSC breakdown →