RND3

Across TCGA patient cohorts, RND3 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RND3-associated genes across cancer lineages are Notch1, Rictor_pT1135, and Cyclin-E2. Each is linked with RND3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RND3-to-partner and partner-to-RND3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by RND3-low versus RND3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RND3→partner) and Y-score (partner→RND3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.206	+2.710	<.001	.003	3	2
UCEC	Rictor_pT1135 →	-0.111	-3.584	.007	.002	3	2
UCEC	Cyclin-E2 →	+0.187	+2.125	.005	.010	3	2
UCEC	14-3-3_beta →	-0.081	-2.295	.045	.033	3	1
UCEC	EGFR_pY1068 →	-0.343	-3.087	<.001	<.001	3	1
UCEC	eIF4E →	+0.210	+3.335	.013	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Notch1 by RND3 expression — UCEC

Explore this box plot interactively →