RNASEL

Across TCGA pan-cancer cohorts, RNASEL mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RNASEL data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RNASEL mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RNASEL expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where RNASEL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	1.000	0.768	.003	39	view →
LSCC	OS	Quartile	All	0.777	0.971	.001	34	view →
LUAD	DFS	Median	II,III,IV	0.773	1.000	.005	6	view →
HNSC	OS	Quartile	All	0.525	1.000	.044	4	view →
GBM	OS	Quartile	All	0.705	0.884	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RNASEL–CCRCC (OS)

Open the CCRCC breakdown →