RNASEL

Across TCGA patient cohorts, RNASEL mutation is significantly associated with the RNA expression of many other genes, with 2,804 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASEL-associated genes across cancer lineages are RNU6-383P, HMGN1P32, and DDX11-AS1. Each is linked with RNASEL in more than 2 cancer types. Because this analysis shows association rather than direction, both RNASEL-to-partner and partner-to-RNASEL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-383P grouped by RNASEL-low versus RNASEL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEL→partner) and Y-score (partner→RNASEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-383P →	+0.186	+2.453	<.001	.005	3	3
UCEC	HMGN1P32 →	+0.084	+1.794	.008	.005	3	3
UCEC	DDX11-AS1 →	+0.344	+2.010	<.001	.005	3	3
UCEC	CENPU →	+0.661	+2.354	<.001	<.001	3	3
COAD	RNU6-618P →	+0.466	+3.686	<.001	.005	3	3
BLCA	B3GNTL1P2 →	+0.090	+3.685	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,804 associations by consensus.

RNU6-383P by RNASEL expression — UCEC

Explore this box plot interactively →