RNASEL

Across TCGA cell cohorts, RNASEL mutation is significantly associated with the RNA expression of many other genes, with 332 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNASEL-associated genes across cancer lineages are ZNF735, CSTL1, and NEUROG1. Each is linked with RNASEL in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASEL-to-partner and partner-to-RNASEL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF735 grouped by RNASEL-low versus RNASEL-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEL→partner) and Y-score (partner→RNASEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF735 →	+0.098	+4.867	<.001	.009	3	2
BLOOD_Lymphoma	CSTL1 →	+0.535	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	NEUROG1 →	+0.006	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	OR4M2 →	+0.031	+4.867	<.001	.009	3	1
STOMACH	IFNL2 →	+0.234	+3.632	<.001	.009	3	1
STOMACH	IFNL3 →	+0.359	+3.632	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 332 associations by consensus.

ZNF735 by RNASEL expression — BLOOD_Lymphoma

Explore this box plot interactively →