RNASEH2C

Across TCGA pan-cancer cohorts, RNASEH2C mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated RNASEH2C data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RNASEH2C mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNASEH2C expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where RNASEH2C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.635	0.916	.001	82	view →
LUAD	DFS	Median	II,III,IV	0.777	0.401	.001	31	view →
UCEC	DFS	Tertile	II,III,IV	0.324	1.000	.005	20	view →
PDAC	DFS	Quartile	All	0.958	0.589	.002	17	view →
GBM	DFS	Tertile	All	0.556	0.241	.005	8	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
CCRCC	DFS	Median	All	0.849	0.976	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

RNASEH2C–HNSC (DFS)

Open the HNSC breakdown →