RNASEH2C

Across TCGA patient cohorts, RNASEH2C mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASEH2C-associated genes across cancer lineages are RNU6-1213P, RN7SL478P, and MIR557. Each is linked with RNASEH2C in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASEH2C-to-partner and partner-to-RNASEH2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1213P grouped by RNASEH2C-low versus RNASEH2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEH2C→partner) and Y-score (partner→RNASEH2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1213P →	+0.258	+4.069	<.001	.008	3	2
UCEC	RN7SL478P →	+0.402	+2.676	<.001	.007	3	1
CESC	MIR557 →	+0.341	+5.342	<.001	.002	3	1
CESC	OR7E93P →	+0.052	+4.812	<.001	.006	3	1
BLCA	RNU6-756P →	+0.333	+7.640	<.001	.009	3	1
CESC	RN7SL73P →	+0.389	+4.276	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

RNU6-1213P by RNASEH2C expression — UCEC

Explore this box plot interactively →