RNASEH2C

Across TCGA cell cohorts, RNASEH2C RNA expression is significantly associated with the go_rna of many other GO terms, with 3,950 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RNASEH2C-associated GO terms across cancer lineages are Centrosome duplication, Microtubule organizing center organization, and Meiotic cell cycle. Each is linked with RNASEH2C in more than 15 cancer types. Because this analysis shows association rather than direction, both RNASEH2C-to-partner and partner-to-RNASEH2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centrosome duplication grouped by RNASEH2C-low versus RNASEH2C-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEH2C→partner) and Y-score (partner→RNASEH2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Centrosome duplication →	+0.117	+0.877	.001	.001	3	16
BREAST	Microtubule organizing center organization →	+0.071	+1.219	<.001	.001	3	14
LUNG_SCLC	Meiotic cell cycle →	+0.066	+0.669	<.001	.001	3	13
PANCREAS	CTP salvage →	+0.121	+0.922	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Centrosome cycle →	+0.095	+1.195	.005	.004	1	14
PANCREAS	Regulation of metaphase plate congression →	+0.142	+1.113	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,950 associations by consensus.

Centrosome duplication by RNASEH2C expression — BONE

Explore this box plot interactively →