RNASEH2B

Across TCGA patient cohorts, RNASEH2B mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASEH2B-associated genes across cancer lineages are Endothelial cells, Erythrocytes, and lymphatic Endothelial cells. Each is linked with RNASEH2B in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASEH2B-to-partner and partner-to-RNASEH2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endothelial cells grouped by RNASEH2B-low versus RNASEH2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEH2B→partner) and Y-score (partner→RNASEH2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Endothelial cells →	-0.045	-3.576	.007	.002	3	1
UCEC	Erythrocytes →	+0.034	+2.241	.001	.031	3	1
UCEC	lymphatic Endothelial cells →	-0.024	-3.660	.020	.001	3	1
UCEC	mv Endothelial cells →	-0.026	-3.584	.011	.002	3	1
UCEC	Basophils →	+0.179	+3.169	.015	.019	3	1
UCEC	NKT →	-0.101	-2.115	.029	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Endothelial cells by RNASEH2B expression — UCEC

Explore this box plot interactively →