RNASEH2B

Across TCGA cell cohorts, RNASEH2B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,799 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNASEH2B-associated GO terms across cancer lineages are Sister chromatid biorientation, Protein localization to chromosome, centromeric region, and Positive regulation of metaphase/anaphase transition of cell cycle. Each is linked with RNASEH2B in more than 13 cancer types. Because this analysis shows association rather than direction, both RNASEH2B-to-partner and partner-to-RNASEH2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sister chromatid biorientation grouped by RNASEH2B-low versus RNASEH2B-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEH2B→partner) and Y-score (partner→RNASEH2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Sister chromatid biorientation →	+0.167	+0.969	.003	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Protein localization to chromosome, centromeric region →	+0.133	+0.885	.001	.001	3	14
LUNG_SCLC	Positive regulation of metaphase/anaphase transition of cell cycle →	+0.141	+0.932	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via synthesis-dependent strand annealing →	+0.079	+0.754	<.001	<.001	3	13
BLOOD_Lymphoma	Metaphase chromosome alignment →	+0.093	+1.217	<.001	<.001	3	13
PANCREAS	Positive regulation of chromosome segregation →	+0.116	+0.866	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,799 associations by consensus.

Sister chromatid biorientation by RNASEH2B expression — LUNG_SCLC

Explore this box plot interactively →