RNASEH2B

Across TCGA cell cohorts, RNASEH2B protein abundance is significantly associated with the go_rna of many other GO terms, with 1,752 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNASEH2B-associated GO terms across cancer lineages are Maintenance of unfolded protein, Positive regulation of mRNA metabolic process, and Positive regulation of mRNA catabolic process. Each is linked with RNASEH2B in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASEH2B-to-partner and partner-to-RNASEH2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of unfolded protein grouped by RNASEH2B-low versus RNASEH2B-high in BLOOD_Lymphoma.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEH2B→partner) and Y-score (partner→RNASEH2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Maintenance of unfolded protein →	+0.099	+1.492	.004	.002	3	2
BLOOD_Leukemia	Positive regulation of mRNA metabolic process →	-0.078	-1.229	.007	.001	3	2
BLOOD_Leukemia	Positive regulation of mRNA catabolic process →	-0.057	-0.975	.003	.003	3	2
BREAST	Positive regulation of interleukin-23 production →	-1.662	-0.583	<.001	.008	3	2
LUNG_NSCLC_LUAD	Rho-activating G protein-coupled receptor signaling pathway →	+0.056	+0.455	.003	.005	3	1
BLOOD_Lymphoma	DNA repair-dependent chromatin remodeling →	+0.102	+1.492	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,752 associations by consensus.

Maintenance of unfolded protein by RNASEH2B expression — BLOOD_Lymphoma

Explore this box plot interactively →