RNASEH2B

Across TCGA cell cohorts, RNASEH2B mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNASEH2B-associated genes across cancer lineages are MAGEB4, STRA8, and ZNF804B. Each is linked with RNASEH2B in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASEH2B-to-partner and partner-to-RNASEH2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by RNASEH2B-low versus RNASEH2B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEH2B→partner) and Y-score (partner→RNASEH2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	DAZ2 →	+0.252	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MAGEB4 by RNASEH2B expression — LARGE_INTESTINE

Explore this box plot interactively →