Across TCGA patient cohorts, RNASE9 mutation is significantly associated with the RNA expression of many other genes, with 777 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASE9-associated genes across cancer lineages are MTND5P35, CENPH, and PPP2R3B. Each is linked with RNASE9 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE9-to-partner and partner-to-RNASE9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE9→partner) and Y-score (partner→RNASE9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MTND5P35 →	+0.031	+5.539	<.001	.004	3	2
UCEC	CENPH →	+0.859	+3.329	<.001	.005	3	2
UCEC	PPP2R3B →	+0.704	+2.711	<.001	.003	3	2
LUAD	GEMIN8P3 →	+0.164	+5.444	<.001	.002	3	2
LUAD	LINC02440 →	+0.643	+4.984	<.001	.005	3	2
UCEC	CDC45 →	+0.810	+3.338	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 777 associations by consensus.

Exploration

RNASE9 survival (RNA) · tumor vs normal (RNA) · all RNASE9 data types