Across TCGA patient cohorts, RNASE9 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASE9-associated genes across cancer lineages are Caspase-7-cleavedD198, Src_pY416, and STAT3_pY705. Each is linked with RNASE9 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE9-to-partner and partner-to-RNASE9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE9→partner) and Y-score (partner→RNASE9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.794	+2.827	.010	.035	3	2
UCEC	Src_pY416 →	-0.279	-3.308	.027	.010	3	1
UCEC	STAT3_pY705 →	-0.531	-2.999	<.001	.035	3	1
UCEC	4E-BP1_pS65 →	-0.256	-3.308	.012	.010	3	1
UCEC	4E-BP1_pT37_T46 →	-0.526	-3.156	.007	.018	3	1
UCEC	c-Kit →	-0.277	-3.321	.023	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

RNASE9 survival (RNA) · tumor vs normal (RNA) · all RNASE9 data types