RNASE7

Across TCGA patient cohorts, RNASE7 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASE7-associated genes across cancer lineages are ERK2, Bax, and MEK1. Each is linked with RNASE7 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE7-to-partner and partner-to-RNASE7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by RNASE7-low versus RNASE7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE7→partner) and Y-score (partner→RNASE7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.264	+3.000	.006	.036	3	1
UCEC	Bax →	+0.343	+2.321	.004	.035	3	1
UCEC	MEK1 →	+0.580	+3.321	.001	.010	2	1
UCEC	JNK2 →	+0.350	+2.321	<.001	.035	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ERK2 by RNASE7 expression — UCEC

Explore this box plot interactively →