RNASE7

Across TCGA cell cohorts, RNASE7 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,233 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible RNASE7-associated GO terms across cancer lineages are Regulation of keratinocyte proliferation, Protein localization to cell-cell junction, and Biological process involved in interaction with host. Each is linked with RNASE7 in more than 7 cancer types. Because this analysis shows association rather than direction, both RNASE7-to-partner and partner-to-RNASE7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of keratinocyte proliferation grouped by RNASE7-low versus RNASE7-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE7→partner) and Y-score (partner→RNASE7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of keratinocyte proliferation →	+0.045	+0.391	.005	.008	3	8
URINARY_TRACT	Protein localization to cell-cell junction →	+0.157	+1.930	<.001	.001	3	7
SOFT_TISSUE	Biological process involved in interaction with host →	+0.063	+0.031	<.001	.001	3	7
PANCREAS	Regulation of fibroblast proliferation →	+0.070	+0.915	.002	.003	3	7
URINARY_TRACT	Cell-substrate junction assembly →	+0.161	+1.587	<.001	<.001	3	7
LUNG_NSCLC_LUAD	Late endosome to lysosome transport →	+0.073	+0.582	<.001	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,233 associations by consensus.

Regulation of keratinocyte proliferation by RNASE7 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →