RNASE6

Across TCGA pan-cancer cohorts, RNASE6 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RNASE6 data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RNASE6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNASE6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

COAD, GBM, and HNSC are the cancer types where RNASE6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.914	1.000	.007	54	view →
GBM	OS	Quartile	All	0.354	0.688	.007	9	view →
HNSC	OS	Median	III,IV	1.000	0.484	.038	5	view →
PDAC	OS	Tertile	All	0.889	0.792	.025	2	view →
LUAD	DFS	Quartile	II,III,IV	0.836	0.303	.026	2	view →
LSCC	OS	Quartile	All	0.961	1.000	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RNASE6–COAD (DFS)

Open the COAD breakdown →