RNASE4

Across TCGA patient cohorts, RNASE4 mutation is significantly associated with the RNA expression of many other genes, with 1,195 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASE4-associated genes across cancer lineages are RPS3AP9, KRTAP4-16, and WASH9P. Each is linked with RNASE4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE4-to-partner and partner-to-RNASE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS3AP9 grouped by RNASE4-low versus RNASE4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE4→partner) and Y-score (partner→RNASE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPS3AP9 →	+0.103	+4.197	<.001	.009	3	2
UCEC	KRTAP4-16 →	+0.113	+3.098	<.001	.002	3	2
UCEC	WASH9P →	+0.551	+3.329	.002	.005	3	1
HNSC	OR4F17 →	+0.108	+5.339	<.001	.003	3	1
HNSC	RNU1-112P →	+0.473	+4.822	<.001	.006	3	1
HNSC	RNU6-332P →	+0.397	+6.132	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,195 associations by consensus.

RPS3AP9 by RNASE4 expression — HNSC

Explore this box plot interactively →