RNASE4

Across TCGA patient cohorts, RNASE4 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASE4-associated genes across cancer lineages are ER-alpha, Notch1, and PAI-1. Each is linked with RNASE4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE4-to-partner and partner-to-RNASE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by RNASE4-low versus RNASE4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE4→partner) and Y-score (partner→RNASE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha →	-1.050	-2.986	.014	.035	3	1
UCEC	Notch1 →	+0.302	+3.321	<.001	.010	3	1
UCEC	PAI-1 →	+0.358	+3.169	.047	.019	3	1
UCEC	Stathmin →	+0.170	+3.321	.018	.010	3	1
UCEC	Caspase-8 →	-0.268	-3.143	.042	.018	3	1
UCEC	PCNA →	+0.436	+3.000	<.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ER-alpha by RNASE4 expression — UCEC

Explore this box plot interactively →