RNASE4

Across TCGA cell cohorts, RNASE4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,263 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible RNASE4-associated GO terms across cancer lineages are Lipid catabolic process, Negative regulation of lymphocyte mediated immunity, and Maintenance of protein localization in endoplasmic reticulum. Each is linked with RNASE4 in more than 11 cancer types. Because this analysis shows association rather than direction, both RNASE4-to-partner and partner-to-RNASE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lipid catabolic process grouped by RNASE4-low versus RNASE4-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE4→partner) and Y-score (partner→RNASE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Lipid catabolic process →	+0.049	+1.806	<.001	<.001	3	12
LUNG_SCLC	Negative regulation of lymphocyte mediated immunity →	+0.146	+1.072	.003	.002	3	11
KIDNEY	Maintenance of protein localization in endoplasmic reticulum →	+0.161	+1.844	.006	.001	3	11
LIVER	Fatty acid beta-oxidation →	+0.123	+2.278	.005	.005	2	11
CNS	Lipid oxidation →	+0.060	+1.016	<.001	<.001	3	10
LUNG_SCLC	tRNA decay →	-0.117	-1.190	.003	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,263 associations by consensus.

Lipid catabolic process by RNASE4 expression — OVARY

Explore this box plot interactively →