RNASE3

Across TCGA patient cohorts, RNASE3 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible RNASE3-associated genes across cancer lineages are Melanocytes, Endothelial cells, and Myocytes. Each is linked with RNASE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE3-to-partner and partner-to-RNASE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Melanocytes grouped by RNASE3-low versus RNASE3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE3→partner) and Y-score (partner→RNASE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Melanocytes →	+0.092	+3.031	.008	.019	3	1
SKCM	Endothelial cells →	-0.046	-2.993	.040	.037	2	1
SKCM	Myocytes →	+0.051	+3.031	.015	.019	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Melanocytes by RNASE3 expression — SKCM

Explore this box plot interactively →