RNASE11

Across TCGA pan-cancer cohorts, RNASE11 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RNASE11 data layer compared with 11 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RNASE11 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RNASE11 expression acts as an unfavorable survival marker.

COAD, LUAD, and UCEC are the cancer types where RNASE11 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.117	0.809	<.001	12	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

RNASE11–COAD (OS)

Open the COAD breakdown →