RNASE10

Across TCGA patient cohorts, RNASE10 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASE10-associated genes across cancer lineages are MEK1, p62 Lck ligand, and Src_pY416. Each is linked with RNASE10 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE10-to-partner and partner-to-RNASE10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RNASE10-low versus RNASE10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE10→partner) and Y-score (partner→RNASE10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.439	+3.000	.016	.036	3	1
UCEC	p62 Lck ligand →	+0.479	+3.009	.003	.019	3	1
UCEC	Src_pY416 →	-0.259	-3.446	.032	.005	3	1
UCEC	STAT3_pY705 →	-0.680	-3.169	<.001	.018	3	1
UCEC	ASNS →	+0.402	+2.321	.026	.035	3	1
UCEC	ATM →	-0.452	-2.321	.047	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MEK1 by RNASE10 expression — UCEC

Explore this box plot interactively →