RNA5SP527

Across TCGA pan-cancer cohorts, RNA5SP527 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of RNA5SP527’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RNA5SP527 RNA is repressed in tumor relative to normal tissue. In most cancer types RNA5SP527 is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

LUAD, BRCA, and COAD are the cancer types where RNA5SP527 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNA5SP527 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−0.860	.001	7	view →
BRCA	Female	All	−0.464	<.001	6	view →
COAD	All	III,IV	−0.350	.007	5	view →
UCEC	All	All	−0.449	.012	4	view →
KIRC	All	All	+0.178	.024	3	view →
KIRP	Male	III,IV	+0.379	.026	2	view →
LUSC	All	All	−0.346	.001	2	view →
THCA	All	All	−0.287	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

RNA5SP527–LUAD

Open the LUAD breakdown →