Across TCGA pan-cancer cohorts, RNA5SP491 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNA5SP491’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where RNA5SP491 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNA5SP491 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

BRCA, BLCA, and STAD are the cancer types where RNA5SP491 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNA5SP491 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	+0.295	.006	4	view →
BLCA	All	All	+0.362	.049	2	view →
STAD	Male	All	+0.191	.017	2	view →
LUAD	All	All	+0.256	.034	1	view →
THCA	All	All	−0.126	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: RNA5SP491 RNA expression & survival · all RNA5SP491 data types