Across TCGA pan-cancer cohorts, RNA5SP466 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNA5SP466’s most consistent transcriptional readouts.
The strongest signal is observed in cholangiocarcinoma (CHOL), where RNA5SP466 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNA5SP466 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
CHOL and THCA are the cancer types where RNA5SP466 tumor–normal differential expression is most reproducible.