Across TCGA pan-cancer cohorts, RNA5SP441 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNA5SP441’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RNA5SP441 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNA5SP441 is over-expressed in tumor.
LUSC and KIRP are the cancer types where RNA5SP441 tumor–normal differential expression is most reproducible.