RNA5SP440

Across TCGA pan-cancer cohorts, RNA5SP440 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNA5SP440’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where RNA5SP440 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNA5SP440 is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.

BRCA, LIHC, and PAAD are the cancer types where RNA5SP440 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNA5SP440 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	+0.347	<.001	6	view →
LIHC	All	II,III,IV	+0.265	.009	3	view →
PAAD	Male	All	−0.669	.005	2	view →
STAD	Male	III,IV	+0.436	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RNA5SP440–BRCA

Open the BRCA breakdown →