Across TCGA pan-cancer cohorts, RNA5SP404 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of RNA5SP404’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RNA5SP404 RNA is repressed in tumor relative to normal tissue. In most cancer types RNA5SP404 is over-expressed in tumor, although a few such as LIHC show the opposite, repressed pattern.
LIHC are the cancer types where RNA5SP404 tumor–normal differential expression is most reproducible.